noun. ['ˈkɔrtəˌzoʊn'] a corticosteroid hormone (trade name Cortone Acetate) normally produced by the adrenal cortex; is converted to hydrocortisone.
1. Noun, singular or mass Monitor the injection site for the first 24 hours after receiving a cortisone shot, as infection is possible. 2. Adjective Although cortisone shots can be very powerful, they do come with some immediate and long-term side effects.